Drug Discovery Research Screening Libraries
AdipoGen Resveratrol
Chemical. CAS 501-36-0. Formula C14H12O3. MW 228.2. Isolated from Polygonum cuspidatum. Potent phenolic antioxidant found in grapes and red wine. Eicosanoid synthesis and platelet aggregation inhibitor. Estrogen receptor agonist. Chemopreventive. Specific inhibitor of cyclooxygenase-1 COX-1. Anti-inflammatory. Ribonucleotide reductase and DNA synthesis. Arrests cell cycle at S/G2 phase. Anticancer and antiproliferative compound. Apoptosis inducer. Protein kinase D inhibitor. Does not inhibit PKC. Autophagy inducer. Potent SIRT1 sirtuin 1 activator. Neuroprotective. Adipogenesis inhibitor. PGC-1alpha activator. Sonic hedgehog Shh signaling pathway modulator. Gli1 mRNA expression inhibitor. Downregulates Gli transcriptional activity. Cardioprotective. Anti-diabetic. Senescence modulator. Extends lifespan. Inhibitor of NLRP3 inflammasome activation.
AdipoGen Lovastatin
Chemical. CAS 75330-75-5. Formula C24H36O5. MW 404.6. Synthetic. Statin compound. Potent competitive HMG-CoA reductase inhibitor. Anti-hypercholesterolemic agent. Cholesterol/isoprenoid biosynthesis inhibitor. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. Inhibits the isoprenylation of Ras and Rho family GTPases. Causes cell cycle arrest in G1 and G2/M phases through modulation of proteasome in cancer cell lines. Smooth muscle cell proliferation inhibitor. Apoptosis inducer. Anticancer compound. Anti-adhesive, immunomodulatory and anti-inflammatory compound. Stimulates bone formation. Increases cellular resistance to anticancer agents such as doxorubicin and etoposide Prod. No. AG-CR1-3572 http//www.adipogen.com/ag-cr1-3572/etoposide.html . Suppresses ICAM-1-LFA-1 interactions, which blocks virus replication and infection. Anti-hypertensive agent. Suppresses TNF-induced NF-kappaB activation.
AdipoGen TIP60 h Hishighly active
Protein. Human TIP60 is fused to a His-tag. Source Sf21 cells. Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50mM imidazole and 10% glycerol. Purity >95% SDS-PAGE. TIP60 is the catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex is required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. TIP60 directly acetylates and activates ataxia-telangiectasia mutated ATM.
AdipoGen Isthmin-1 h rec
Recombinant Protein. Human isthmin-1 aa 30-464 is fused at the C-terminus to a His-tag. .Source HEK 293 cells. Endotoxin content <0.01EU/µg purified protein LAL test.. Lyophilized. Contains PBS. Purity >95% SDS-PAGE. Isthmin-1 ISM1 was first identified as a gene expressed in the Xenopus midbrain hind brain organizer called isthmus, with a proposed role during early brain development. Isthmin-1 encodes a predicted ~50-kDa protein containing a signal peptide, a thrombospondin domain and an adhesion-associated domain. Isthmin-1 is important for embryonic and postnatal development. Growing evidence has shown that aberrant expression of Isthmin-1 can also affect the biological behavior of cancer. The Ism1 gene is conserved in mice and humans. A recent study showed that Ism1 is an adipokine that induces glucose uptake in human and mouse adipocytes.
AdipoGen DNER ED hFc h rec
Protein. The extracellular domain of human DNER aa 29-637 is fused at the C-terminus to the Fc portion of human IgG1. Source HEK 293 cells. Endotoxin content <0.06EU/µg purified protein LAL test Lonza. Lyophilized from 0.2µm-filtered solution in PBS. Purity >90% SDS-PAGE. DNER is an activator of the Notch1 pathway. It mediates neuron-glia interaction during astrocytogenesis.
AdipoGen ANGPTL4 FLD h rec
Protein. Fibrinogen-like domain of human ANGPTL4 aa 166-406 is fused at the N-terminus to a FLAG -tag. Source HEK 293 cells. Endotoxin content <0.1EU/µg purified protein LAL test Lonza. Liquid. 0.2µm-filtered solution in PBS. Purity >90% SDS-PAGE. ANGPTL4 Angiopoietin-like protein 4 mainly expressed in endothelial cells hypoxia-induced. Regulates angiogenesis and modulates tumorigenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 is a protein consisting of an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain FLD. Both domains have distinct biological functions. The coiled-coil domain is responsible for the inhibitory effects on lipoprotein lipase LPL converting the active form of LPL into an inactive form, and the FLD domain mediates its antiangiogenic functions.
AdipoGen Vaspin h rec MultiPack
Protein. Human vaspin aa 21-414 is fused at the N-terminus to a FLAG -tag. Source HEK 293 cells. Endotoxin content <0.01EU/µg purified protein LAL test Lonza. Lyophilized. Contains PBS. Purity >95% SDS-PAGE. Vaspin Visceral adipose tissue-derived serpin Serpin A12, a serine protease inhibitor serpin, is an insulin-sensitizing adipocytokine that has been isolated from both visceral and subcutaneous white adipose tissue. Based on recent findings, vaspin is suggested to regulate immune responses and inflammation and was found to be correlated with various metabolic parameters. Vaspin may represent a novel biomarker for obesity and impaired insulin sensitivity and might serve as a new therapeutic target of metabolic syndrome.
AdipoGen Progranulin h untagged
Protein. Signal peptide and human progranulin aa 1-593 is untagged. Reflects the native sequence with no additional aa. Source HEK 293 cells. Endotoxin content <0.01EU/µg purified protein LAL test Lonza. Lyophilized. Contains PBS. Purity >98% SDS-PAGE. Progranulin PGRN is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration FTLD. In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease AD and potentially for MCI Mild Cognitive Impairment. Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
AdipoGen Hexamethonium bromide
Chemical. CAS 55-97-0. Formula C12H30Br2N2. MW BD9837. Hexamethonium bromide is a peripherally-acting nondepolarizing neuromuscular blocking agent that acts as a non-competitive antagonist of nicotinic acetylcholine receptors nAChRs. Formulations containing hexamethonium were previously used in the treatment of hypertension. Induces apoptosis and inhibits the stimulatory effect of nicotine on endothelial cell DNA synthesis and proliferation.
AdipoGen Glucuronolactone
Chemical. CAS 32449-92-6. Formula C6H8O6. MW 176.12. Synthetic. Naturally occurring carbohydrate derivative that is an important structural component of nearly all connective tissues and is also found in many plant gums. Metabolized to glucaric acid, xylitol, and L-xylulose, and humans may also be able to use glucuronolactone as a precursor for ascorbic acid synthesis. Used as a detoxicant. The liver uses glucose to create glucuronolactone, which inhibits the enzyme B-glucuronidase metabolizes glucuronides, which should cause blood-glucuronide levels to rise. Glucuronides combine with toxic substances, such as morphine and depot medroxyprogesterone acetate, by converting them to water-soluble glucuronide-conjugates which are excreted in the urine. Used as building block and starting reagent for synthesis of drugs, optically active glucopyranoses and long-chain alkyl glucofuranosides.
AdipoGen C7-L-HSL
Chemical. CAS 177158-20-2. Formula C11H19NO3. MW 213.3. Synthetic. N-Heptanoyl-L-homoserine lactone C7-HSL is a small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism. The diverse applications of this molecule include regulation of virulence, infection prevention and septicemia in fish.
AdipoGen D-Fructose 1 6-diphosphate 3Na
Chemical. CAS 38099-82-0. Formula C6H11Na3O12P2 . xH2O. MW 406.06 anhydrous basis. Synthetic. D-Fructose-1,6-bisphosphate FBP, a common metabolic sugar, is the precursor of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic pathway. It is an allosteric activator of enzymes such as pyruvate kinase and a substrate used to identify and characterize enzymes such as fructose-1,6-bisphosphate aldolases and fructose-1, 6-bisphosphatases. FBP is studied as a neuroprotective agent in brain injury.
AdipoGen L-Glutamine
Chemical. CAS 56-85-9. Formula C5H10N2O3. MW 146.14. L-Glutamine is an amino acid and is essential in the formation of purine and pyrimidine nucleotides, amino sugars, glutathione, L-glutamate and other amino acids as well as in protein synthesis and glucose production. It plays also a role in lipid synthesis e.g. in cancer cells, cellular energy as a source next to glucose, nitrogen donation for many anabolic processes, including the synthesis of purines and carbon donation, as a source refilling the citric acid cycle. It is a nontoxic transporter of ammonia in the blood circulation and a precursor to the neurotransmitter glutamate and GABA. L-Glutamine is an essential amino acid which is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine exerts potent antioxidant and anti-inflammatory effects, next to its roles in cell proliferation and cancer.
AdipoGen Folic acid
Chemical. CAS 59-30-3. Formula C19H19N7O6. MW 441.4. Synthetic. Folic acid, also known as folate, is a B vitamin is an essential nutritional component of the human diet. It is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis, and for preventing changes to DNA, and consequently cancer. It is especially important during periods of frequent cell division and growth, such as infancy and pregnancy. Folate is needed to carry one-carbon groups for methylation reactions and nucleic acid synthesis. Folic acid deficiency hinders DNA synthesis and cell division, affecting hematopoietic cells and neoplasms the most because of their greater frequency of cell division. Both adults and children need folate to make normal red and white blood cells and prevent anemia. Deficiency of folic acid in pregnant women has been implicated in neural tube defects NTD.
AdipoGen L-Glutathione reduced
Chemical. CAS 70-18-8. Formula C10H17N3O6S. MW 307.32. Synthetic. Major tripeptide widely distributed in both plants and animals. Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Regulates activity of the redox sensitive transcription factor NF-kappaB. Cytoprotective. Serves as a nucleophilic co-substrate to glutathione transferases in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of hydroperoxides. Involved in amino acid transport and maintenance of protein sulfhydryl reduction status. Posseses several metabolic, regulatory and protective functions. Forms disulfide bonds with cysteine residues in proteins.